Abstract
M ounting interest has been generated over the past decade concerning the potential beneficial effects of n-3 fatty acids on atherosclerosis and atherothrombotic disorders. Substantial quantities of epidemiological and laboratory data have accumulated regarding n-3 fatty acids and atherosclerosis.<sup>1,2</sup>The purpose of this review is to summarize recent studies that have sought to elucidate the biochemical and cellular effects by which n-3 fatty acids might favorably affect atherogenesis. We will begin with a very brief review of the clinical and epidemiological data. <h3>EPIDEMIOLOGICAL, CLINICAL, AND EXPERIMENTAL OBSERVATIONS</h3> Epidemiological studies of Greenland and Alaskan Eskimos have demonstrated a substantially reduced mortality rate of ischemic heart disease in these populations compared with European and North American cohorts.<sup>3,4</sup>Analysis of the Eskimo diet revealed differences from typical Western diets, especially in the fatty acid content, which contained substantial quantities of n-3 fatty acids derived from marine sources.<sup>5</sup>Similar studies in
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