N-(2, 6-dichlorophenyl)-o-aminophenylacetic acidおよびそのNa塩ならびにN-(2, 6-dichlorophenyl)-anthranilic acidおよびNa塩の抗炎症作用

Abstract

The actions of title compounds on acute inflammation were examined and compared to such structural analogous as mefenamic acid (MA) and flufenamic acid (FA) or such antiinflammatory agents as phenylbutazone (PB) and indomethacin (IM). In the anti-inflammatory effects tested in oral administration, no significant difference was observed between free and sodium compounds. In the inhibitory effects on increased vascular permeability and acute edema, No. 1 compound showed a more potent activity than MA, FA and PB, while No. 2 compound had an activity similar to MA. The inhibitory effect of test compounds on carrageenin edema did not decrease in adrenalectomized rats. Both No. 1 and No. 2 compounds revealed a markedly inhibitory action on ultraviolet erythema as well as fenamates. Neither showed antagonistic effects on the mediators (except for serotonin) and urine volume was not increased. The test compounds were considered to have a similarly specific anti-inflammatory activity to the known anti-inflammatory agents and compound (No. 1) which substituted carbonic acid of anthranilic acid to acetic acid was found to have a more potent anti-inflammatory action than the original compound (No. 2).