Abstract
A group of eleven patients in end-stage renal failure who developed proximal weakness is described. The muscle weakness in all cases was shown to be myopathic in nature by quantitative electromyography. Four of the patients presented with muscle dysfunction and were found to have severe osteomalacia secondary to renal disease. In these patients vitamin D in high doses produced some improvement in muscle weakness. In the other patients who were on maintenance dialysis, muscle weakness improved dramatically after renal transplantation or dialysis with deionized water. There were no quantitative differences between the two groups as far as muscle weakness was concerned. However it is suggested that metabolic bone disease may be one pathogenic factor in the first group and that some aspect of renal failure per se (or its treatment by dialysis) may predominate in the second and contribute to the first.
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