Abstract
We describe acute myopathy following I-131 treatment for hyperthyroidism due to Graves Disease (GD) in an adolescent. A 15 year-old diagnosed with GD required treatment with radioactive iodine (I-131) therapy. Six weeks post I-131, he developed generalized muscle cramps. The CK was 19.800 U/L, the total thyroxine was 2.3 mcg/dL (29.6 nmol/L SI) and the estimated free thyroxine (EFT) was 0.5 ng/dL (6.4 pmol/L SI). The ALT was 112 U/L and AST was 364 U/L (normal <35 U/L). The muscle cramps and CK elevation normalized five months after initiation of thyroid replacement therapy. This observation shows that acute myopathy can rarely occur in pediatric patients with GD following treatment with I-131.
Highlights
Graves Disease (GD) is uncommon in children with an estimated incidence of 1 per 10,000 [1]
We describe acute myopathy following I-131 treatment for hyperthyroidism due to GD in an adolescent
Acute myopathy in GD was initially reported in an adult treated with 131-I, who presented with muscle cramps and creatine kinase (CK) elevation six weeks after treatment, a condition that resolved with the correction of the hypothyroid state [16]
Summary
Section of Endocrinology, Department of Pediatrics, Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, CT 06520, USA. We describe acute myopathy following I-131 treatment for hyperthyroidism due to Graves Disease (GD) in an adolescent. A 15 year-old diagnosed with GD required treatment with radioactive iodine (I-131) therapy. Six weeks post I-131, he developed generalized muscle cramps. The ALT was 112 U/L and AST was 364 U/L (normal
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
