Abstract
Myofibroma is a mesenchymal neoplasm that occurs mostly in children and adolescents. This report describes a case of myofibroma with extensive myxoid changes. A 17-year-old man was referred for diagnosis of a lesion, of 4 months' duration, located in the right submandibular region. Clinically, a mobile and painless nodule measuring 4 cm was observed. The lesion was excised under local anesthesia. Microscopically, a neoplasm formed by large and elongated spindle-shaped cells arranged in a biphasic pattern, with cellular and acellular areas, was observed. There were extensive myxoid areas. The tumor cells presented a strong positivity for alpha-smooth muscle actin and vimentin, and negativity for S-100 and CD34. Based on these features, the diagnosis was myofibroma with extensive myxoid areas. No recurrence was observed after 18 months. Although myxoid changes are extremely rare findings, myofibromas should be considered in spindle-shaped cell tumors with such features.
Published Version
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