Abstract
Myofibroblastic sarcoma (MS) has been described as a rare malignant mesenchymal tumor showing myofibroblastic differentiation, with a predilection for the head and neck region. We report a case of an aggressive MS in a 27-year-old male patient presenting as an ulcerated mass affecting the posterior mandible region. Radiographic images showed diffuse bone destruction. Histopathologic analysis revealed an intense proliferation of fusiform and round highly pleomorphic cells, randomly arranged in a vascularized and myxoid stroma. Immunohistochemically, tumor cells were positive for vimentin, smooth muscle actin, and calponin. The Ki-67 proliferation index was high. S-100 protein, desmin, pan-cytokeratin (AE1AE3), CD99, and h-caldesmon were negative. Hence, a diagnosis of myofibroblastic sarcoma was yielded. After the incisional biopsy, the lesion rapidly increased in size. The patient was admitted to intensive care and started a chemotherapy regimen but died 3 months later.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call