Abstract
Objective To characterize immunohistochemically a group of oral myofibroblastic lesions (MLs). Study Design MLs incorporated during the period of 1997-2014 were retrieved from the files and records of the Department of Oral Pathology. Cases of myofibroma (MF), nodular fasciitis (NF), desmoplastic fibroma (DF), and 2 myofibroblastic sarcoma (MS) were stained with antibodies against alpha-smooth muscle actin (α-SMA), H-caldesmon, vimentin, desmin, β-catenin, anaplastic lymphoma protein kinase (ALK-1), and Ki-67. Results Nineteen of 22 cases of MF, 2/5 NF, 1/10 DF, and 1/2 MS were positive for α-SMA. All cases of MF, NF, DF, and MS were positive for vimentin. One-half of MS cases were positive for desmin. Six out of 10 cases of DF were positives for β-catenin. Two cases of MF were positive for ALK-1. All cases of MF, NF, DF, and MS were negative for H-caldesmon. The Ki-67 labeling index was 10% and 8/22 cases of MF, 3/5 cases of NF, and 2/2 cases of MS exhibited a rate of ≥ 10% for this marker. Conclusions The application of this panel of markers can help the diagnosis of oral MLs, in particular the distinction between fibroblastic, myofibroblastic, and muscle cells proliferation.
Published Version
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