Abstract
In this study we investigated the postnatal developmental changes in sarcomeric protein expression in parallel with contractile parameters in myofibrils isolated from small resections from the right ventricular (RV) outflow tract in 25 patients with Tetralogy of Fallot and related congenital heart diseases (CHD). These CHDs are associated with RV hypertrophy and outflow tract obstruction. The age of the patients ranged from 4 days to 38 months. The resections were procured during surgical correction of the cardiac malformation and would have been otherwise discarded.
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