Abstract
Myocarditis heart failure: A review of clinical status and meta-analyses of diagnostic performance of cardiac magnetic resonance and therapeutic value of immunosuppressive therapy
Highlights
Heart failure (HF) is the culmination of many forms of heart diseases
The leading heart and cardiology societies such as American Heart Association (AHA) [3] and European Society of Cardiology (ESC) Working Group on Myocardial and Pericardial Diseases [4] refer to myocarditis as one of the causes of dilated cardiomyopathy (DCM) or a form of inflammatory cardiomyopathy
Studies were eligible for inclusion if they met the following criteria: (a) were randomized controlled prospective or retrospective clinical trials; (b) recruited patients suspected with myocarditis or inflammatory DCM with reduced ejection fraction; (c) evaluated diagnostic performance of cardiac magnetic resonance (CMR) using endomyocardial biopsy (EMB) as reference standard; and (d) provided sufficient data to compared diagnostic performance of CMR against EMB
Summary
Heart failure (HF) is the culmination of many forms of heart diseases. It manifests as signs and symptoms suggesting cardiac dysfunction. No population-based epidemiological study has comprehensively documented the range of clinical manifestations of acute or chronic myocarditis likely because of varied modes of clinical presentation and the lack of reliable non-invasive cardiac imaging tests reduces the yield of conclusive diagnostic or prognostic value [6]. It allows the assessment of cardiac chamber sizes and wall thickness as well as systolic and diastolic function in patients suspected with myocarditis It is an important non-invasive imaging tool to exclude other causes of HF such as valvular heart disease or other cardiomyopathies such as hypertrophic or restrictive. Studies were eligible for inclusion if they met the following criteria: (a) were randomized controlled prospective or retrospective clinical trials; (b) recruited patients suspected with myocarditis or inflammatory DCM with reduced ejection fraction; (c) evaluated diagnostic performance of CMR using EMB as reference standard; and (d) provided sufficient data to compared diagnostic performance of CMR against EMB. The findings suggests EMB remains the gold standard for confirmatory diagnosis of myocarditis and a need to develop newer parameters or imaging technique to improve CMR diagnostic performance
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