Abstract
Objective. To study the etiology of nonischemic ventricular arrhythmias and to improve diagnostic evaluation of inlammatory myocardial disease using endomyocardial biopsy.Design and methods. We performed 100 endomyocardial biopsies during catheter ablation in patients with nonischemic ventricular arrythmias. Results. Myocarditis was veriied in 58 cases, and postinlammatory ibrosis — in 24 cases. Twenty three patients (67 %) demonstrated active myocarditis, 1 (2,9 %) had chronic active myocarditis, and 10 subjects (29 %) — chronic non-active myocarditis. Conclusion. Endomyocardial biopsy contributes to better veriication of the etiology of ventricular arrhythmias. Late gadolinium enhancement during magnetic resonance imaging shows 74 % sensitivity and 46,9 % speciicity in the evaluation of myocarditis, and 52,4 % sensitivity and 38,9 % speciicity in veriication of postinlammatory ibrosis. Presence of CD-8+ cells, Ig M, patchy dystrophin expression can be additional features for veriication of active myocarditis.
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