Abstract
The compositions of myocardial triacylglycerol fatty acid (TGFA) and serum free fatty acids (sFFA) were examined in control and streptozotocin-induced diabetic rats. After 12 days of diabetes, the rats were killed and the hearts excised and perfusion-washed. Tissue lipids were extracted and fractioned by sequential column, thin-layer, and gas-liquid chromatography. Results showed a marked increase in total TGFA content of the diabetic myocardium. In addition, compositions of TGFA and sFFA were altered. The compositional changes were similar, involving a shift from 16-carbon fatty acids to 18-carbon fatty acids (primarily stearate and linoleate). The change in TGFA composition was reversible with insulin treatment.
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