Myocardial oxygenation and contractile function during graded reduction of coronary flow.

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In the isolated perfused heart, several studies have shown that there is a linear relationship between coronary flow and myocardial contractile function (1–7). The severe reductions of coronary flow decreases high energy phosphate compounds and increases lactate production. In contrast, the mild reductions cause only reduction in contractile function but not high energy compounds (2,4,5,7,8). Under such conditions it is supposed that reduced energy consumption (oxygen demand) balances the reduced oxygen supply (4,6).KeywordsCoronary FlowContractile FunctionPerfuse HeartOxygen DependenceCoronary Flow RateThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.