Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Abstract

Nitric oxide and other free radicals in cardiac physiology and pathology.- Neural regulation of coronary vascular resistance: Role of nitric oxide in reflex cholinergic coronary vasodilation in normal and pathophysiologic states.- The potential of antioxidants to prevent atherosclerosis development and its clinical manifestations.- Nitric oxide in coronary artery disease: Roles in atherosclerosis, myocardial reperfusion and heart failure.- The roles of free radicals, peroxides and oxidized lipoproteins in second messenger system dysfunction.- Nitric oxide: An endogenous cardioprotectant?.- Ionic and electrophysiological aspects in myocardial ischemia and reperfusion.- Intracellular calcium regulatory systems during ischemia and reperfusion.- The pH paradox in ischemia-reperfusion injury to cardiac myocytes.- Electrophysiological responses to ischemia and reperfusion.- Cellular mechanisms of cardiac arrhythmias in the ischemic and reperfused heart.- Biochemical factors in myocardial ischemia and reperfusion.- Bioenergetics, ischemic contracture and reperfusion injury.- Lipid metabolism in the ischemic and reperfused heart.- Signal transduction mechanisms in the ischemic and reperfused myocardium.- Hormonal, autocrine, and paracrine factors in myocardial ischemia and reperfusion.- The role of endothelins in cardiac function in health and disease.- Role of kinins in myocardial ischemia.- Role of eicosanoids in the ischemic and reperfused myocardium.- The role of the neutrophil in myocardial ischemia and reperfusion.- Role of the sympathetic nervous system in the ischemic and reperfused heart.- Protection strategies against myocardial ischemia and reperfusion.- Sodium-hydrogen exchange in myocardial ischemia and reperfusion: A critical determinant of injury?.- The role of ATP-sensitive potassium channels in myocardial ischemia: Pharmacology and implications for the future.- Cardioprotective actions of adenosine and adenosine analogs.- Myocardial protection for cardiac surgery.- Endogenous cardioprotective adaptive mechanisms.- Ischemic preconditioning against infarction: Its mechanism and clinical implications.- The molecular basis of adaptation to ischemia in the heart: The role of stress proteins and antioxidants in the ischemic and reperfused heart.- Ischemia and reperfusion in the diabetic and hypertrophied myocardium.- Response to ischemia and reperfusion by the diabetic heart.- Ischemia and reperfusion injury in the hypertrophied heart.- The stunned and hibernating myocardium.- Myocardial stunning: A post-ischemic syndrome with delayed recovery.- The hibernating myocardium.- Post-infarction myocardial responses.- Mechanisms of subcellular remodelling in post-infarct heart failure.- Tissue angiotensin II and myocardial infarction.- Structural remodeling of the infarcted rat heart.- Pharmacological intervention in post-infarction wound healing.