Abstract
Background Chronic iron overload is prevalent and prognosis relates to the severity of cardiac siderosis. The black blood (BB) T2* technique is validated, with calibration against myocardial tissue iron at 1.5T. There are potential advantages of 3T over 1.5T in assessing T2*, but preliminary studies at 3T used white blood imaging, had small patient numbers, methodological differences, and poor signal-noise ratio in severe iron overload precluding assessment across a wide dynamic range. A novel noise correction (NC) algorithm is superior to other techniques in severe iron loading. We assessed BB T2* iron measurement at 3T against the 1.5T gold standard and incorporated the NC algorithm. Methods
Highlights
Chronic iron overload is prevalent and prognosis relates to the severity of cardiac siderosis
A novel noise correction (NC) algorithm is superior to other techniques in severe iron loading
There was good intra-observer, inter-observer and interstudy reproducibility of black blood (BB) T2* measurement at 3T with coefficients of variation (CoV) of 3.1%, 4.0% and 6.5%, these were inferior to 1.5T CoV, which were 1.6%, 2.8% and 4.4% respectively
Summary
Mohammed H Alam1,2*, Gillian C Smith, Taigang He1, John Paul Carpenter, Arun J Baksi, Ricardo Wage, Peter Drivas, Karen Symmonds, David Firmin, Dudley J Pennell. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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