Ultrafast Magnetic Resonance Imaging for Iron Quantification in Thalassemia Participants in the Developing World: The TIC-TOC Study (Thailand and UK International Collaboration in Thalassaemia Optimising Ultrafast CMR).

Abstract

HomeCirculationVol. 134, No. 5Ultrafast Magnetic Resonance Imaging for Iron Quantification in Thalassemia Participants in the Developing World Open AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toOpen AccessLetterPDF/EPUBUltrafast Magnetic Resonance Imaging for Iron Quantification in Thalassemia Participants in the Developing WorldThe TIC-TOC Study (Thailand and UK International Collaboration in Thalassaemia Optimising Ultrafast CMR) Amna Abdel-Gadir, MRCP, Yongkasem Vorasettakarnkij, MD, Hataichanok Ngamkasem, MD, Sabrina Nordin, MRCP, Emmanuel A. Ako, MRCP, Monravee Tumkosit, MD, Pranee Sucharitchan, MD, Noppacharn Uaprasert, MD, Peter Kellman, PhD, Stefan K. Piechnik, PhD, Marianna Fontana, PhD, Juliano L. Fernandes, PhD, Charlotte Manisty, PhD, Mark Westwood, MD, John B. Porter, MD, J. Malcolm Walker, MD and James C. Moon, MD Amna Abdel-GadirAmna Abdel-Gadir From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). *Drs Abdel-Gadir and Vorasettakarnkij are joint first authors. Search for more papers by this author , Yongkasem VorasettakarnkijYongkasem Vorasettakarnkij From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). *Drs Abdel-Gadir and Vorasettakarnkij are joint first authors. Search for more papers by this author , Hataichanok NgamkasemHataichanok Ngamkasem From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Sabrina NordinSabrina Nordin From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Emmanuel A. AkoEmmanuel A. Ako From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Monravee TumkositMonravee Tumkosit From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Pranee SucharitchanPranee Sucharitchan From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Noppacharn UaprasertNoppacharn Uaprasert From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Peter KellmanPeter Kellman From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Stefan K. PiechnikStefan K. Piechnik From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Marianna FontanaMarianna Fontana From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Juliano L. FernandesJuliano L. Fernandes From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Charlotte ManistyCharlotte Manisty From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , Mark WestwoodMark Westwood From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , John B. PorterJohn B. Porter From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author , J. Malcolm WalkerJ. Malcolm Walker From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author and James C. MoonJames C. Moon From Institute of Cardiovascular Science, University College London, UK (A.A.-G., S.N., E.A.A., M.F., C.M., J.M.W., J.C.M.);Barts Heart Centre, London, UK (A.A.-G., S.N., E.A.A., C.M., M.W., J.C.M.); Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Y.V., M.T., P.S., N.U.); Queen Savang Vadhana Memorial Hospital, Sriracha, Thailand (H.N.); Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute, Bethesda, MD (P.K.); University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, UK (S.K.P.); National Amyloidosis Centre, Royal Free Hospital, London, UK (M.F.); Cardiovascular Imaging Center, Jose Michel Kalaf Research Institute, Sao Paulo, Brazil (J.L.F.); Haematology Department, University College London Hospitals, UK (J.B.P.); and Hatter Cardiovascular Institute, University College Hospital, London, UK (J.M.W.). Search for more papers by this author Originally published2 Aug 2016https://doi.org/10.1161/CIRCULATIONAHA.116.022803Circulation. 2016;134:432–434Thalassemia is the most common monogenetic disorder worldwide, with 60 000 infants with thalassemia major born annually.1 Survival often depends on regular blood transfusions to correct anemia and to reduce ineffective erythropoiesis, but these transfusions can result in iron overload and organ failure unless chelation therapy is undertaken. Serum ferritin levels continue to be used as a guide to chelation but are unreliable, and the availability of cardiovascular magnetic resonance (CMR) T2* imaging has transformed patient management by allowing organ-specific quantification of iron content.2,3Countries with a high prevalence of thalassemia major have CMR, but magnet time is expensive and analytic expertise lacking. The aim of TIC-TOC (Thailand and UK International Collaboration in Thalassaemia Optimising Ultrafast CMR) was to investigate whether ultrafast CMR mapping could provide reliable immediate diagnoses of heart and liver iron content, eliminating the need for complex analysis, thus reducing costs to a level within local resources. The research received approval by the Institutional Review Board of the Faculty of Medicine at Chulalongkorn University. All participants provided written informed consent.One hundred participants with thalassemia major were recruited by the local support group at the King Chulalongkorn Memorial Hospital in Bangkok, Thailand. Eleven healthy volunteers not on cardio-active medication were recruited through local hospital advertising to confirm normal ranges. All participants underwent magnetic resonance imaging scans with a 1.5-T scanner (Aera, Siemens) calibrated with the T1MES (T1 Mapping and ECV Standardisation in CMR) phantom.4 The scan consisted of 10 breath holds: localizer and pilot images, myocardial and liver T2* and T1 mapping, anatomic half-Fourier acquisition single-shot turbo spin echo stack, and long-axis left ventricular steady-state free-precession cines with an optional short-axis cine stack (2 breath holds) if abnormal, but none were. Both modified look-locker inversion recovery (MOLLI) and shortened MOLLI (MyoMaps, Siemens) T1 mapping sequences were implemented. T2* and native T1 maps were performed on the same mid left ventricular short-axis slice. The black-blood T2* sequence consisted of 8 or 12 echoes (2.68–20.11 milliseconds; 2.49-millisecond increments for the heart; 12 in the transverse plane for the liver; minimum echo time, 0.99 millisecond). Images were analyzed as they were acquired, providing assessment of myocardial and liver iron, function, and extracardiac anatomy.For the myocardial maps, a single septal region of interest was manually traced. For the liver T2* maps, a large region of interest was traced, avoiding vasculature. Liver T1 values were obtained from the myocardial short-axis images. The 11 healthy volunteers all had normal scans. The lower limit of normal for T1 was taken as 2 SD below the mean and 20 millisecond for myocardial T2*.2,3Ferritin and hemoglobin blood levels were measured. One-year average ferritin values were calculated from a minimum of 3 values per patient.Of the 100 participants invited, 97 were scanned; 2 participants were unwell and 1 patient consented but was claustrophobic (Table). Visual left ventricular function assessment on long-axis cines was normal in all participants, including those with cardiac iron. In total, including test-retest, 123 scans were performed in 2 days (12-hour working days). Mean scan duration was 8.3±2.4 minutes with complete analysis within 1 minute of the last image acquisition.Table. Participant Baseline CharacteristicsCharacteristicsValuen97Age, y34.1±12.1Sex, M/F31/66Height, m1.57±0.08Weight, kg50.7±9.2BSA, m21.48±0.16Chelation DFO, n13 DPO, n63 Deferasirox, n6 DFO+DPO, n5 DPO+deferasirox, n2 None, n8MRI scanning duration, min8.3±2.4Myocardial T2*, ms29.5±7.9Myocardial iron by T2* <20 ms (participant frequency, %)15 (15.5)Liver T2*, ms2.5±1.4Liver iron by T2* <6.3 ms (participant frequency, %)96 (98.9)Average ferritin, μg/L3533±2897Hemoglobin, g/dL8.03±1.24Average ferritin over 1 year. Data are presented as mean±SD when appropriate. BSA indicates body surface area; DFO desferrioxamine; DPO, deferiprone; and MRI, magnetic resonance imaging.Fifteen participants had myocardial iron loading by T2* (10 severe, 2 moderate, 3 mild). There was good correlation between myocardial T2* and T1 maps (T2* versus MOLLI, r2=0.81; T2* versus shortened MOLLI, r2=0.83; both P<0.0001). All participants with low myocardial iron T2* had low T1 values. Thirty participants with normal T2* had low T1 MOLLI values (<982 milliseconds). Ninety-six participants had liver iron by T2*(46 severe, 33 moderate, 17 mild); only 1 patient had a normal liver T2* value. Liver T2* mapping correlated with T1 mapping (T2* versus MOLLI, r2=0.33; T2* versus shortened MOLLI, r2=0.36; P<0.0001).There was a weak correlation between myocardial and liver T2* maps and mean ferritin values (r2=0.17 and r2=0.15, respectively; both P<0.0001). There was no correlation with ferritin in severe myocardial and liver iron.TIC-TOC demonstrated the clinical and economic advantages of ultrafast magnetic resonance imaging protocols, scanning 6 participants per hour for two 12-hour days, reducing scanning costs by a factor of ≈4. Mapping analysis took minimal training, required <1 minute, and was reliable (data not shown). Mapping revealed a 15% prevalence of abnormal cardiac iron content by T2* and 45% by T1. High liver iron was detected in 99%. This study has demonstrated that ultrafast scanning is achievable with the use of sequences available on commercially available CMRs and scanners. Thus, widespread adoption of this approach is feasible and currently being investigated by the Global-AID project, which is endeavoring to distribute this technology to multiple countries to confirm applicability and cost-effectiveness and to investigate potential changes in outcomes.Amna Abdel-Gadir, MRCP*Yongkasem Vorasettakarnkij, MD*Hataichanok Ngamkasem, MDSabrina Nordin, MRCPEmmanuel A. Ako, MRCPMonravee Tumkosit, MDPranee Sucharitchan, MDNoppacharn Uaprasert, MDPeter Kellman, PhDStefan K. Piechnik, PhDMarianna Fontana, PhDJuliano L. Fernandes, PhDCharlotte Manisty, PhDMark Westwood, MDJohn B. Porter, MDJ. Malcolm Walker, MDJames C. Moon, MDAcknowledgmentsWe thank the patients, staff, and Chulalongkorn Thalassemia Support Group for their valuable contributions. We wish to acknowledge Andreas Greiser from Siemens AG Healthcare Sector.Sources of FundingDr Abdel-Gadir is supported by the Rosetrees Trust and UK Thalassaemia Society. Drs Vorasettakarnkij, Ngamkasem, Tumkosit, Sucharitchan, and Uaprasert are supported by the Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University (grant RA58/058). Dr Porter is supported by the British Research Council. Dr Piechnik is supported by the National Institute for Health Research Oxford Biomedical Research Center based at The Oxford University Hospitals Trust at the University of Oxford. Drs Moon and Manisty are supported by the UK National Institute for Health Research Biomedical Research Center funding scheme.DisclosuresNone.Footnotes*Drs Abdel-Gadir and Vorasettakarnkij are joint first authors.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Circulation is available at http://circ.ahajournals.org.Correspondence to: Amna Abdel-Gadir, MRCP, Barts Heart Centre, London, UK EC1A 7BE. E-mail [email protected]