Myocardial hypertrophy: Effect of physical load and hypertension on the formation of cardiac prostanoids and fatty acid composition of cardiac phospholipids

Abstract

Rodents trained by swimming were found to develop mild myocardial hypertrophy associated with increased production of cardioprotective prostanoids and intensification of linoleic acid metabolism in cardiac phospholipids. Rats with pathologic heart hypertrophy related to hereditary hypertension displayed a reduction in the production and secretion of cardiac prostanoids, which is explained by inhibited metabolism of a number of polyunsaturated fatty acids (PUFA) in cardiac phospholipids. On the basis of the findings obtained, the authors propose techniques to prevent heart overexertion during physical loads by optimizing the exercise pattern and combining an optimal training regimen with a diet enriched by linoleic acid to increase the generation of cardioprotective prostanoids.