Myocardial fatty acid metabolism probed with hyperpolarized [1-13C]octanoate

Hikari Yoshihara,Mathilde H Lerche,Juerg Schwitter,Jessica A Bastiaansen,Magnus Karlsson,Arnaud Comment

doi:10.1186/1532-429x-17-s1-o101

Hikari Yoshihara, Mathilde H Lerche + Show 4 more

Open Access

https://doi.org/10.1186/1532-429x-17-s1-o101

Copy DOI

Abstract

Background The heart normally derives most of its energy from the oxidation of fatty acids. Myocardial metabolism can be monitored non-invasively by MRS using hyperpolarized (HP) 13C-labelled compounds; however, the vast majority of studies reported have used HP pyruvate and did not measure fatty acid catabolism. The myocardial metabolism of HP [1-13C]butyrate and [1-13C]acetate has been reported. The conversion of these short-chain fatty acids to acetyl-CoA does not involve successive rounds of beta-oxidation, as is the case for longer chain fatty acids, which are a more important source of cardiac energy. In this study we examined the applicability of hyperpolarized [1-13C]octanoate, a medium-chain fatty acid, as a probe of myocardial metabolism.

Highlights

The heart normally derives most of its energy from the oxidation of fatty acids
In this study we examined the applicability of hyperpolarized [1-13C]octanoate, a medium-chain fatty acid, as a probe of myocardial metabolism
The chemical shift of the metabolite was assigned to [1-13C]acetylcarnitine. This was confirmed by infusing HP [1-13C]acetate and observing [1-13C]acetylcarnitine with the same chemical shift, as well as coinfusing HP [1-13C]acetate and [113C]octanoate and observing a single metabolite peak for [1-13C]acetylcarnitine

Summary

Introduction

The heart normally derives most of its energy from the oxidation of fatty acids. Myocardial metabolism can be monitored non-invasively by MRS using hyperpolarized (HP) 13C-labelled compounds; the vast majority of studies reported have used HP pyruvate and did not measure fatty acid catabolism. Myocardial fatty acid metabolism probed with hyperpolarized [1-13C]octanoate Background The heart normally derives most of its energy from the oxidation of fatty acids. Myocardial metabolism can be monitored non-invasively by MRS using hyperpolarized (HP) 13C-labelled compounds; the vast majority of studies reported have used HP pyruvate and did not measure fatty acid catabolism.

Results

Conclusion