Abstract
The clinical investigations shows that myocardial diastolic dysfunction develops already at early stages of I type diabetes mellitus. The purpose of our work was to reveal disturbances of myocardial relaxation function in rats with streptozotocin-induced diabetes and to investigate possible mechanisms of such infringements development. On Langendorff isolated heart, the essential increase of left ventricular diastolic stiffness (considered as ΔEDP/ΔV) was shown at experimental diabetes. At dosed left ventricular stretching with balloon, the sharp growth of EDP meanings in diabetic hearts was observed at significantly smaller value of balloon volume gain, than in control hearts.
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