Abstract
A number of reports have now appeared demonstrating a marked inhibition of the mitochondrial oligomycin-sensitive ATPase as the result of the interruption of blood flow (ischemia) in a number of tissues including liver,1,2 kidney,3,4 skeletal muscle5 and cardiac muscle.6–9 By and large, the ATPase inhibition observed in ischemic tissues appears to be reversible if blood flow is resumed early enough,2,4,6,9 suggesting that this inhibition represents a regulatory response of the oligomycin-sensitive ATPase complex to one or more metabolic alterations within the ischemic cells.
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