Myocardial and Skeletal Muscle Bioenergetics

Abstract

I. Microcompartmentation and Energy Transport.- The Physiological Significance of the Creatine Phosphate Shuttle.- Organization of the Mitochondrial Matrix.- The Time Course of ATP Cleavage by Contracting Amphibian and Mammalian Skeletal Muscles.- Isozymes of Creatine Kinase in Mammalian Myocardial Cell Culture.- Microcompartmentation at the Mitochondrial Surface: Its Function in Metabolic Regulation.- The Effect of Inorganic Phosphate on Mitochondrial Creatine Kinase.- Hormonal Regulation of Creatine Kinase BB.- Compartmentation of Adenine Nucleotides and Phosphocreatine Shuttle in Cardiac Cells: Some New Evidence.- Compartmentation of Hormone Action in Adult Mammalian Cardiomyocytes.- Function of Creatine Kinase Localization in Muscle Contraction.- Isotope Labeling Ratios: A Tool for the Exploration of Metabolic Compartments.- The Mitochondrial Creatine Phosphokinase is Associated with Inner Membrane Cardiolipin.- A Role for Mitochondria in Myocardial Adenosine Production.- II. Respiration Control - Cellular and Organ Level.- Aspects of Heart Respiratory Control by the Mitochondrial Isozyme of Creatine Kinase.- Control of Respiration in Intact Muscle.- Energy Compartmentation and Active Transport in Proximal Kidney Tubules.- The Oxygen Dependence of Cellular Energy Metabolism.- Regulation of Mitochondrial Respiration in Liver.- Quantitation of Fluxes in the Gluconeogenic, Glycolytic, and Pentose Phosphate Pathways in Isolated Rat Hepatocytes: Energetic Considerations.- Why is There a Delay in the Increased Oxygen Consumption During the Rest-Work Transition in Skeletal Muscles.- III. Myocardial Preservation, Ischemia: Cellular Mechanisms.- Compartmentation and Functional Mechanisms in Myocardial Failure and Myocardial Infarction.- Myocardial Protection of Hypertrophied Hearts by Administration of Cardioplegia According to Regional Myocardial Temperature.- Heart Myocytes as Models of the Cellular Response to Ischemia.- Biologic Basis for Limitation of Infarct Size.- Mitochondrial Transmembrane Proton Electrochemical Potential, Di- and Tricarboxylate Distribution and the Poise of the Malate-Aspartate Cycle in the Intact Myocardium.- Sarcomere Length-tension Relationship in Toad Atrioventricular Pacemaker: Length Dependent Activation.- Myocardial Acidosis and the Mitigation of Tissue ATP Depletion in Ischemic Cardiac Muscle: The Role of the Mitochondrial ATPase.- Vascular Metabolism and Energetics.- Myocardial Glutamate Dehydrogenase Activity.- Long Term Model for Evaluation of Myocardial Metabolic Recovery Following Global Ischemia.- The Effect of Reperfusion and Streptokinase on Ischemic Myocardium Serum Creatine Kinase Activity, MM Subtypes and Myocardial Blood Flow.- Post-contracture Reperfusion: Effect of Elevated Potassium and Verapamil.- Ultrastructure of the Human Myocardium after Intermittent Ischemia Compared to Cardioplegia.- IV. Pathophysiology of Energy Compartmentation.- Cellular Injury in Phosphate Depletion: Pathogenesis and Mechanisms in the Myocardium.- Diabetes Mellitus and Hypothyroidism Induce Changes in Myosin Isoenzyme Distribution in the Rat Heart - Do Alterations in Fuel Flux Mediate These Changes?.- Glycerol Kinase Deficiency: Compartmental Considerations Regarding Pathogenesis and Clinical Heterogeneity.- Phosphorylated Nucleotides and Glycolytic Intermediates in Diabetic and Non-diabetic Rat uterus in Late Pregnancy.- Effect of Calcium Antagonists on Vasopressin Induced Changes in Myocardial and Renal Pyridine Nucleotides in the Intact Rat.- The Effect of Creatine Analogue Substitution on the Post Tetanic Response of Fast Muscle.- V. Divalent Ions and Cellular Bioenergetics.- Calcium Compartmentation in Mammalian Myocardium.- Calcium Channel Blockers, Beta Blockers and the Maintenance of Calcium Homeostasis.- Sodium-Calcium Exchange: Calcium Regulation at the Sarcolemma.- The Calcium Pumping ATPase of Heart Plasma Membrane.- Calcium Compartmentation and Regulation in Myocytes.- Ca++-Dependent and Ca++-Independent Effects of Mg++ on Canine Right Atria.- Chronotropic and Inotropic Effects of [Mg++]o Not Dependent upon [Ca++]o.- Sodium Modulation of Resting Force, Contractile Properties, and Metabolism with Particular Emphasis on its Role in the Development of Calcium Overload States.- The Effect of Short Chain Fatty Acid Administration on Hepatic Glucose, Phosphate, Magnesium and Calcium Metabolism.- VI. 31-P NMR.- Lessons for Muscle Energetics from 31P NMR Spectroscopy.- Metabolic Depletion Preceding Cytolysis Induced by Antibody and Complement as Revealed by 31P-NMR Spectroscopy.