Abstract
A 52-year-old man with a history of multiple myeloma presented with unilateral loss of vision and evidence of infiltrative optic neuropathy as the sole manifestation of diffuse myelomatous meningitis. He received systemic and intrathecal chemotherapy along with radiation, and did not develop any additional neurologic deficits. The optic neuropathy in this case was thought to be due to infiltration of the optic nerve and meninges by plasma cells. In spite of extensive CNS involvement, including other cranial nerves, the only clinical symptom of myelomatous meningitis was decreased vision in one eye.
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