Abstract
Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In addition, MAAs are also involved in the modulation of skin fibroblasts proliferation. However, the regulatory function of MAAs on wound repair in human skin is not yet clearly elucidated. To investigate the roles of MAAs on the wound healing process in human keratinocytes, three MAAs, Shinorine (SH), Mycosporine-glycine (M-Gly), and Porphyra (P334) were purified from Chlamydomonas hedlyei and Porphyra yezoensis. We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. This study also indicates that MAAs can act as a new wound healing agent and further suggests that MAAs might be a novel biomaterial for wound healing therapies.
Highlights
In recent years, natural products from marine organisms have gained increasing research interest and potential economic importance as a number of novel compounds have been reported from different marine organisms [1,2,3,4]
Characterization of Mycosporine-like amino acids (MAAs) MAAs were identified based on their retention time during high-resolution reverse-phase liquid chromatography (HPLC) and their UV absorption spectra obtained from diode array detection (DAD)
DAruAgss 2w01e5,re13,i7d0e5n5t–i7f0i6e6d based on their retention time during high-resolution reverse-phase liquid chromatography (HPLC) and their UV absorption spectra obtained from diode array detection (DAD)
Summary
Natural products from marine organisms have gained increasing research interest and potential economic importance as a number of novel compounds have been reported from different marine organisms [1,2,3,4]. The increasing number of reports on the presence of MAAs in different marine species refers mostly to their potential photo protective properties [10]. Owing to the positive effects on cell regeneration observed in human skin fibroblasts, MAAs seem to be potential cosmeceutical agents [13,14,15]. In contrast with the abundant literature available on the functional roles of MAAs on the skin, there are no previous reports elucidating their beneficial effects on the wound healing process. Tight regulation and activation of several signaling proteins involved in wound healing play crucial roles in the repair process. We examined the potential roles of three MAAs, mycosporine-glycine (M-Gly), shinorine (SH), and porphyra (P334) in wound healing. We investigated the potential molecular mechanisms underlying the MAAs-mediated wound healing process
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
