Abstract
Persistent infection of Mycoplasma hyorhinis (M. hyorhinis) is associated with various types of cancer. However, to date, there is few study identifying host factors mediating its infection and its effect on cancer patients’ prognosis also remains unknown. Recently, we reported for the first time that M. hyorhinis infects mammalian cells and promotes gastric cancer cell invasiveness via its membrane protein p37, and host Annexin A2 (ANXA2) is the cell receptor mediating M. hyorhinis infection. Downstream of ANXA2, NF-kB pathway is activated and mediates M. hyorhinis -driven cell migration. Furthermore, we demonstrated that M. hyorhinis p37 protein expression in gastric cancer tissues positively correlates with tumor metastasis and predicts poor survival. In conclusion, our study uncovers the mechanism by which M. hyorhinis infects mammalian cells and promotes cancer cell migration and unveils the effect of M. hyorhinis infection on gastric cancer survival.
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