Abstract
<div>Abstract<p>Chronic infection of <i>Mycoplasma hyorhinis</i> (<i>M. hyorhinis</i>) has been postulated to be associated with several types of cancer, but its effect on patients' survival and host factors mediating its infection remain unclear. Herein, we demonstrated that <i>M. hyorhinis</i> p37 protein expression in gastric cancer tissues predicts poor survival and associates with metastasis. <i>M. hyorhinis</i> infects mammalian cells and promotes gastric cancer cell invasiveness via its membrane protein p37. Synthesized peptide corresponding to the <i>N</i>-terminus of p37 prevents <i>M. hyorhinis</i> infection. Host Annexin A2 (ANXA2) interacts with the <i>N</i>-terminus of p37. In addition, EGFR forms a complex with p37 and ANXA2, and is required for <i>M. hyorhinis</i>–induced phosphorylation and membrane recruitment of ANXA2. <i>M. hyorhinis</i> infection is inhibited by siRNA-mediated knockdown of ANXA2 or EGFR, but is enhanced by expression of ectopic ANXA2 or EGFR. Downstream of ANXA2 and EGFR, the NF-κB pathway is activated and mediates <i>M. hyorhinis</i>–driven cell migration. In conclusion, our study unveils the effect of <i>M. hyorhinis</i> infection on gastric cancer survival and uncovers the mechanisms by which <i>M. hyorhinis</i> infects mammalian cells and promotes cancer cell migration. <i>Cancer Res; 74(20); 5782–94. ©2014 AACR</i>.</p></div>
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