Abstract
MYC and MiR: vicious circle
Highlights
Increasing evidence suggests that a dynamic interaction occurs between the lymphoma cell and its microenvironment (TME, stroma), with each profoundly influencing the behavior of the other
When applied these models to determine the functional role of miRNAs and miRNA-regulated proteins in TME-mediated drug resistance and lymphoma progression, a global miRNA expression profiling was performed and revealed that expression of multiple miRNAs is altered in lymphoma cells upon adhesion to HK cells [4]
Given that MYC overexpression promotes lymphoma progression by inducing proliferation and makes the lymphoma cells prone to apoptosis, a concomitant stroma-activated pro-survival signal pathway is essential to cooperate with MYC in lymphoma TME to confer lymphoma cell survival advantage, drug resistance and proliferation potential
Summary
Increasing evidence suggests that a dynamic interaction occurs between the lymphoma cell and its microenvironment (TME, stroma), with each profoundly influencing the behavior of the other. When applied these models to determine the functional role of miRNAs and miRNA-regulated proteins in TME-mediated drug resistance and lymphoma progression, a global miRNA expression profiling was performed and revealed that expression of multiple miRNAs is altered in lymphoma cells upon adhesion to HK cells [4].
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