Abstract
Multi-phonon resonance Raman scattering (MRRS) has shown significant promise in clinical diagnosis and medical research. However, the limited intensity of MRRS signal has impeded its advancement and practical application. Herein, Ti3C2Tx MXene was employed to composite with ZnS and amplify the MRRS signal of ZnS, resulting in an impressive enhancement factor of up to 1.5 × 107. This ZnS/Ti3C2Tx MXene composites was subsequently utilized as bioprobes for the highly sensitive and reliable detection of glial fibrillary acidic protein (GFAP), achieving a limit of detection (LOD) of 104.4 ag mL−1 with a linear range spanning from 1 fg mL−1 to 10 ng mL−1. This represents a three-order decrease in the LOD and an extension of the linear range by three orders of magnitude compared to that of ZnS bioprobes. The successful detection of serum GFAP further validates the clinical potential of this technique. This work introduces a novel strategy for effectively enhancing MRRS. It also provides a method for the adjustment of semiconductor electron-phonon coupling property and thus hopefully in the improvement of optoelectronic performance.
Published Version
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