Abstract
Objective: We have recently identified a novel gene, Great, which causes infertile bilateral intra-abdominal cryptorchidism in homozygous Great knockout mice. Here, we performed mutation screening of the human GREAT gene using denaturing high-pressure liquid chromatographic (DHPLC) analysis of cryptorchid patients. Relaxin is known to activate the GREAT receptor through the adenosine 3,5-monophosphate (cAMP)-dependent pathway. We used relaxin to analyze the functional properties of the mutant receptor that was identified.
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