Abstract
Solutions of nucleic acid bases, nucleosides and a nucleotide, saturated with either N 2, N 2O or O 2, were irradiated and tested for mutagenicity towards Salmonella typhimurium, with and without pre-incubation. Irradiated solutions of the nucleic acid bases were all non-mutagenic. Irradiated solutions of the nucleosides showed mutagenicity in S. typhimurium TA100 (pre-incubation assay). Generally, the mutagenicity followed the order: N 2O > N 2 > O 2. The results show that the formation of mutagenic radiolytic products is initiated by attack of mainly OH radicals on the 2-deoxy- d-ribose moiety of the nucleosides. With irradiated solutions of the nucleotide, thymidine-5′-monophosphate, no mutagenicity could be detected.
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