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Abstract
The two antimalarial agents chloroquine and mefloquine have been tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537 and TA1538. Chloroquine was found to revert strain TA1537 at concentrations of 100 and 250 μg/ml, most likely due to intercalation. No mutagenicity was found with mefloquine at concentrations up to 2.5 μg/ml, neither without nor with metabolic activation by Ca 2+-precipitated rat liver microsomes. Higher concentrations of mefloquine and chloroquine inactivated the bacteria.
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