Abstract
Mushrooms containing the chemical coprine include Coprinus atramentaria, formerly called Coprinus atramentarius (commonly known as inky cap or Tippler's Bane). Other Coprinus species, however, do not contain coprine including the edible Coprinus comatus (Shaggy Mane or Lawyer's wig). Coprine is the chemical responsible for the well-known toxicity of these mushrooms, which occurs when ethanol is ingested within hours to days of coprine-containing mushrooms. Coprine, like the therapeutic drug disulfiram (also known as Antabuse) inhibits aldehyde dehydrogenase, which is responsible for the metabolism of acetaldehyde when ethanol is consumed. Accumulation of acetaldehyde causes systemic toxicity including nausea, vomiting, headache, and hemodynamic changes including tachycardia and hypotension.
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