Abstract
Muscle tenderness and psychiatric comorbidity: a vicious cycle in migraine chronicization.
Highlights
This comorbidity between affective disorders and migraine seems to result from bidirectional influences, where each disorder increases the risk for first onset of the other
Growing evidence suggests that psychiatric comorbidity may be a risk factor for migraine chronicization [6]
Society (IHS) [14], where infrequent, frequent and chronic tension-type headache can be associated with increased pericranial muscle tenderness
Summary
This comorbidity between affective disorders and migraine seems to result from bidirectional influences, where each disorder increases the risk for first onset of the other. Such bidirectional relationship between migraine and affective disorders may be underpinned by shared genetic or epigenetic factors able to increase the risk of both conditions [8]. Along with shared genetic features, other common pathophysiological factors, such as neuronal excitability and vascular endothelial dysfunction [10, 11], might play a role in the relationship between migraine and psychiatric disorders.
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