MUSCLE FUNCTION & HOMEOSTASIS / MOLECULAR THERAPEUTIC APPROACHES: P.73 Depletion of ATP limits membrane excitability of skeletal muscle by increasing both ClC1-open probability and membrane conductance

Abstract

Activation of skeletal muscle contractions require that action potentials can be excited and propagated along the muscle fibers. It is known that muscle fiber excitability is regulated during repeated firing of action potentials by cellular signalling systems that control the function of ion channels that determine the resting membrane conductance (Gm). In fast-twitch muscle, prolonged firing of action potentials triggers a marked increase in Gm, reducing muscle fiber excitability and causing action potential failure.