Abstract
Fifteen AKR thymic lymphoma lines were studied for presence or absence of T-and B-cell membrane markers, immunoglobulin (Ig), Fc- and C′-receptors. All tumors carried Thy-1 antigen and mouse-specific lymphocyte antigen (MSLA), and 9 out of 14 tumors were thymus leukemia alloantigen (TL) positive. Bone-marrow-derived lymphocyte antigen (MBLA) was expressed on none of these tumors. This is strong evidence that the tumor cells are malignant variants of normal T cells. The biosynthesis of Ig was shown for one T tumor. Ig on this tumor was present on the membrane of all cells. The Ig was a molecule which reacted with anti-μλ antiserum. It had the size of a 10S molecule. Several of the tumors expressed Fc-receptors (FcR) for the constant portion of the γ-chain, preferentially IgG2b. One tumor was positive for Ig and FcR. C′-receptors were not found on any of the tumor lines. The results are discussed with the concept that the tumors might be a model for the study of T cells. Evidence is presented that membrane properties of the tumors are also found in normal T-cell subpopulations. It is suggested that the tumors represent the physiological variety of T cells and that they might help to solve the problem of the T-cell receptor for antigen.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call