Abstract
Publisher Summary This chapter discusses the multiple lymphocyte surface antigens of the mouse. A wide range of different antigens is described, ranging from those that have a broad tissue distribution to those highly restricted to specific lymphocytes and including others, such as viral-associated antigens. Special emphasis is placed on the Ly markers, in view of their extreme utility in defining functional subsets of lymphocytes. The new Qa antigens and the Ia system are also discussed. It describes genetic polymorphisms that lead to structural variations in the cell surface. These variations lead to differences between strains that subsequently elicit the production of antibody or graft rejection. The studies of cell membrane alloantigenic determinants (CMAD) have yielded generous rewards, particularly in the identification of the relationship between T-cell function and surface antigenic phenotype. The CMAD is used to distinguish among different functional subpopulations of lymphocytes. There are a number of examples where CMAD and murine leukemia virus are associated either directly or indirectly. Viral antibodies contaminating alloantisera are providing considerable problems in the analysis of CMAD.
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