Abstract
Abstract It has long been recognized that B cells lack phagocytic capabilities. Until recently, B cells from teleost fish were shown to have potent phagocytic abilities for particle antigens; however, whether mammalian B cells are able to accomplish phagocytosis is still not clear. Here we demonstrated that mouse peritoneal cavity (PerC) B-1 B cells, which are thought to be the counterpart of the teleost fish blood B cells, had in vivo and in vitro phagocytic activities to Staphylococcus aureus and polystyrene fluorescent microspheres. Ingestion of particles by B cells led to activation of degradative pathways, resulting in phagolysosome formation and intracellular killing of ingested microbes. About 10% of PerC B cells, mostly CD11b+ B-1 B cells, showed phagocytic activities, and there was no apparent difference between B-1a and B-1b cells in the capabilities for phagocytotisis. Spleen B cells showed a very low degree of phagocytosis. Our results revealed for the first time that mammalian B-1 B cells have phagocytic capacities, which may contribute to their role in innate and adaptive immunity.
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