Abstract
BackgroundIn the present work, an electrochemical sensor for detection of paracetamol was fabricated by modifying a glassy carbon electrode (GCE) using multiwalled carbon nanotube (MWCNT) decorated with bismuth oxide (Bi2O3) based on using the drop dry technique.MethodsThe prepared composite electrode was characterized by scanning electron microscopy–energy dispersive X-ray spectroscopy (SEM–EDS), Fourier transform infrared spectroscopy (FT-IR), and cyclic voltammetry (CV). Electrochemical techniques such as cyclic voltammetry, chronoamperometry, and square wave voltammetry (SWV) were used to study the behavior of paracetamol.ResultsThe modification process improved the redox kinetics of paracetamol as shown by increased peak currents. The peak current varied linearly with increment of paracetamol concentration in the range of 0.02 to 28 μM with a sensitivity of 1.133 μA μM−1. A detection limit of 0.0052 μM was obtained.ConclusionThe proposed method was successfully applied to determination of paracetamol in biological samples with recoveries in the range 94.3–98.7%.
Highlights
Paracetamol (Scheme 1) is mainly used as an antipyretic and analgesic drug in most countries for relief of mild to moderate pain associated with headache, arthritis, backache, toothaches, and postoperative pain (Jia et al 2007; Kachoosangi et al 2008; Devaraj et al 2013)
A cheap composite prepared from multiwalled carbon nanotube (MWCNT) and Bismuth oxide (Bi2O3) was used with the intent to exploit their synergistic effects
The Scanning electron microscopy–energy dispersive X-ray (EDS) spectrum of MWCNT shows an intense peak for the element carbon
Summary
The modification process improved the redox kinetics of paracetamol as shown by increased peak currents.
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