Abstract
Kruse, S., Kvalheim, O.M., Gadeholt, G., Halsteinslid, L. and Sletten, E., 1991. Multivariate analysis of proton NMR spectra of serum from rabbits. Monitoring progressive growth of implanted VX-2 carcinoma. Chemometrics and Intelligent Laboratory Systems, 11: 191–196. Proton NMR spectra of serum from rabbits have been subjected to multivariate data analysis in order to monitor the progress of malignant disease. Two groups of rabbits had VX-2 carcinoma implanted in the thigh and in the kidney, respectively. Another group was also subjected to chemotherapy treatment. In addition, a group of healthy rabbits was given an injection of physiological saline. Digitally defined parts of the spectral profiles of the lipoprotein methylene and methyl signals were used as input to a principal component analysis (SIMCA). The controls were modelled as one group, where six principal components accounted for 98.7% of the total variance in the data. The calculated residuals were used as a screening criterion. At a probability level of 0.01 ( F-test) samples from implanted rabbits were classified as malign as soon as the tumors developed. Progressive cancerous growth could be monitored by a concomitant increase in residuals. The rabbits with saline injection had no significant increase in residuals over the same time period.
Published Version
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