Abstract
To explore the relationship between various molecular makers and liver metastasis of colorectal cancer (CRC). Using immunohistochemistry, protein expression of CEA, nm23, c-met, MMP2, COX- 2, VEGF, EGFR, and CD44 was assessed in 80 CRC cases. The Chi-square test and logistic regression were performed to analyze the relationship between these indicators and CRC liver metastasis. There were significant differences in expression of CEA, MMP2, CD44, VEGF and EGFR between the liver metastasis and non metastasis groups (P < 0.05); no significant differences were noted for nm23, c-met, and COX-2 expression. Logistic regression analysis showed that only CEA, VEGF, and EGFR entered into the regression equation, and had significant correlations with CRC liver metastasis (α inclusion= 0.10, α elimination = 0.15, R2 = 0.718). Combination detection of CEA, VEGF, and EGFR may be an effective means to predict CRC liver metastasis. Nm23, c-met, MMP2, COX-2, and CD44, in contrast, are not suitable as prognostic markers.
Highlights
Colorectal cancer (CRC) is a clinically common seen malignant tumor and the second leading cause of cancer death in the western country (Chung-Faye et al, 2000)
Logistic regression analysis showed that only carcinoembryonic antigen (CEA), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) entered into the regression equation, and had significant correlations with colorectal cancer (CRC) liver metastasis (α inclusion= 0.10, α elimination = 0.15, R2 = 0.718)
Recent studies indicate that many molecular factors play important roles in CRC, such as carcinoembryonic antigen (CEA) (Bakalakos, 1999), tumor suppressor nm23 (Yamaguchi et al, 1993), tyrosine kinase receptor c-met (Zeng et al, 2008), matrix metalloproteinases 2 gene (MMP2) (Okada et al, 2001), cyclooxygenase 2 (COX-2) (Yao et al, 2004), vascular endothelial growth factor (VEGF) (Tokunaga et al, 1998), epidermal growth factor receptor (EGFR) (Kuramochi et al, 2010), and celladhesion molecule CD44 (Nanashima et al, 1999)
Summary
Colorectal cancer (CRC) is a clinically common seen malignant tumor and the second leading cause of cancer death in the western country (Chung-Faye et al, 2000). Method: Using immunohistochemistry, protein expression of CEA, nm23, c-met, MMP2, COX2, VEGF, EGFR, and CD44 was assessed in 80 CRC cases. Results: There were significant differences in expression of CEA, MMP2, CD44, VEGF and EGFR between the liver metastasis and non metastasis groups (P < 0.05); no significant differences were noted for nm23, c-met, and COX-2 expression.
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