Abstract
The prodromal phase of type I diabetes is characterized by the presence of a series of autoantibodies reacting with distinct autoantigens [anti-insulin, anti-64 kDa, islet cell antibodies ('antiganglioside')]. Anti-insulin autoantibodies appear to be unique in that the levels of such antibodies correlate with both the rate of progression to diabetes and age at which type I diabetes develops. With a combination of assays it is now possible to predict type I diabetes, allowing the design of research trials for diabetes prevention.
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