Abstract
We present a 23 years old Caucasian female patient with multiple sclerosis and Chronic Cerebrospinal Venous Insufficiency, treated by venous angioplasty of the extracranial veins. The presence of Chronic Cerebrospinal Venous Insufficiency (CCSVI) was detected by a sonogram of both Internal Jugular and Vertebral Veins with assessing grey scale appearance, color Doppler flow and transcranial sonogram of the deep cerebral veins using Quality Doppler Processing Technology (QDP). The genetic analyses disclosed aneuploidy DNA content by flow cytometry analysis. A Magnetic Resonance follow up is recommended to patients and their first degree relatives.
Highlights
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the Central Nervous System (CNS)
The clinical course of the disease is variable, it usually leads to progressive deterioration and severe disability [1]
A dramatic correlation between MS and the presence of 2 or more of the 5 criteria of venous outflow abnormalities was reported. This led the authors to a highly criticized hypothesis that chronically impaired venous drainage of the CNS may trigger the initiation of an inflammatory process leading to MS [7,8]
Summary
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the Central Nervous System (CNS). A dramatic correlation between MS and the presence of 2 or more of the 5 criteria of venous outflow abnormalities was reported This led the authors to a highly criticized hypothesis that chronically impaired venous drainage of the CNS (termed “Chronic Cerebrospinal Venous Insufficiency”, CCSVI) may trigger the initiation of an inflammatory process leading to MS [7,8]. Our protocol for endovascular treatment of CCSVI included balloon angioplasty in the IJVs and the azygos vein with the aim of restoring blood flow, not necessarily achieving a perfect angiographic result. After achieving optimal results on the functionally significant lesions and performing final angiography, the guidewire and the introducer was removed and homeostasis was established by manual compression After the procedure her concentration and memory improved significantly, the numbness she felt in her arms and hands disappeared and her stamina improved. The flow cytometry analysis revealed an aneuploid DNA content in blood sample between the father and the daughter of the family and not the mother (Figure 2)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
