Abstract
Is infection with the Epstein-Barr virus the long-debated cause of multiple sclerosis? A new study has now added to the mounting evidence supporting this hypothesis: it analyzed the T cell receptor β-chain repertoires of 1,395 MS patients and found more TCRβ sequences specific to the virus in MS patients than in healthy individuals. These findings are consistent with the hypothesis that MS is associated with an ongoing immune response to the Epstein-Barr virus that goes awry, leading to central nervous system damage. They also seem to be independent of differences in genetics or early environmental factors.
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