Abstract
This paper reviews evidence that the presence of mast cells in specific sites of central nervous system, suggesting inflammatory processes, may explain all the symptoms observed in multiple sclerosis. This hypothesis would be relatively easy to test.
Highlights
This paper reviews evidence that the presence of mast cells in specific sites of central nervous system, suggesting inflammatory processes, may explain all the symptoms observed in multiple sclerosis
It has been widely accepted that multiple sclerosis (MS) is an autoimmune, genetic disease
MS does nearly not exist in Africa, Indian subcontinent, and the West Indies, yet children of immigrants from these areas born in UK show the same high prevalence of MS as the endogeneous population [6]
Summary
It has been widely accepted that multiple sclerosis (MS) is an autoimmune, genetic disease. Migration studies indicate that some parts of the disposition for MS are already acquired by the age 15 in high-risk areas, and that MS is an environmental disease ordinary acquired in adolescence with an incubation period before symptom onset [7]. The raised concordance rate in dizygotic twins is compatible with the hypothesis that events at early part of life are important in determining the subsequent risk of MS [16] From all these facts we conclude that multiple sclerosis is unlikely to be a genetic disease
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