Multiple Organ Failure Syndrome In Patients With Acute Diffuse Peritonitis

Abstract

The results of the surgical treatment of 123 patients with acute diffuse peritonitis have been analyzed. The dynamics of necrotic processes activity in the mucous membrane of the small intestine according to its affection marker I-FABP, the liver – LFABP and of the heart – H-FABP in preoperative period and on 1, 3, 5, 7 day after the operation. Due to the level of multiple organ failure according to G.R. Bernard et al. scale (1995) and the level of bacterial contamination of the abdominal cavity during the operative treatment of patients with acute diffuse peritonitis, the choice of the method (closed and open) of intestinal intubation, programmed laparostomia is indicated. The methods of pharmacological (inotropic, antibacterial, infusion) correction of multiple organ failure syndrome during a comprehensive treatment of patients in toxic and terminal stages of acute diffuse peritonitis are worked out enabling to reduce the frequency of post-operational complications from 73,6% to 39,1%, and to reduce the level of post-operational lethal outcome from 14,1% to 8,5%.