Abstract
Multiple Metastatic Small Cell Carcinoma of Unknown Primary Diagnosed on Inguinal Node Biopsy
Highlights
Metastatic cancer of unknown primary (CUP) accounts for 3-5% of all malignant neoplasms
We describe an uncommon case of inguinal lymph node small cell metastasis of unknown origin, accompanied by multiple sites of involvement
At FDG positron emission tomography (PET), the lungs, the liver, the spleen and the pancreas revealed no tracer uptake raising the suspicion of hematological disease or diffuse metastatic melanoma
Summary
Canc Therapy & Oncol Int J Copyright © All rights are reserved by Capizzello Antonio. Multiple Metastatic Small Cell Carcinoma of Unknown Primary Diagnosed on Inguinal Node. Differentiated neuroendocrine tumors are uncommon neoplasms of the lung and the gastrointestinal tract. 3-5% of these tumors are diagnosed as metastatic disease with unknown primary. We describe a case of neuroendocrine small cell carcinoma of unknown primary diagnosed by inguinal node biopsy. A 53-year-old male patient with a history of heavy smoking presented with cough, back pain and altered mental status. Whole body imaging studies (CT – MRI – FDG PET) favored a diagnosis of hematological disease (lymphoma) or diffuse metastatic melanoma. Inguinal node biopsy revealed morphological and immunohistochemical features of a neuroendocrine carcinoma, probably originating from the lung. The patient received palliative whole brain irradiation and etoposide/platinum-based chemotherapy
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