Multiple Lymphomatous Polyposis Form of Blastoid Variant of Mantle Cell Lymphoma in Colon: a Case Report and Review of Literature

Abstract

Primary non-Hodgkin's lymphoma (NHL) of the gastrointestinal tract is the most common extranodal NHL and accounts for 4–20 % of all NHL. Primary gastrointestinal lymphoma is most frequently diagnosed in the stomach and less frequently in the colon. Primary colorectal lymphomas are very uncommon, accounting for only 0.2 % of large intestinal malignancies [1, 2]. Multiple lymphomatous polyposis (MLP) is an extremely rare form of primary gastrointestinal (GI) lymphoma, which is characterized by multiple polyps formed by neoplastic lymphoid cells. It was for the first time described in 1961 by Cornes, and till now, approximately 70 detailed cases have been reported in the literature [3, 4]. Most of the MLP arise from the mantle cell lymphoma, whereas the rest originate from mucosal-associated lymphoid tissue (MALT) lymphoma or follicular lymphoma. The blastoid variant of mantle cell lymphoma has blastoid cytology with round to oval, large nuclei along with prominent nucleoli, in contrast to the much more common classic mantle cell lymphoma, having smallto medium-sized nuclei with irregular nuclear contours. Most of the cases that have been presented in literature are classic mantle cell lymphoma with typical cytology and low proliferation index [1–5]. Case Presentation