Abstract
An analysis of the evolutionary dynamics of the regulatory mechanisms that give rise to the conserved histone regulatory phenotype indicates a substantial evolutionary turnover of cis-regulatory sequence motifs along with the transcription factors that bind them
Highlights
Core histone genes are periodically expressed along the cell cycle and peak during S phase
Gene expression patterns The expression of core histone genes is tightly regulated during the cell cycle and peaks during S phase, concomitant with DNA replication (Figure 2)
A number of recent studies have revealed the extent to which this S phase specific pattern of core histone gene expression is conserved among eukaryotic species; the histone expression pattern has been demonstrated for human core histone genes as well as for histones from S. cerevisiae and S. pombe [8,9,10,11,12,13]
Summary
Core histone genes are periodically expressed along the cell cycle and peak during S phase. Core histone gene expression is deeply evolutionarily conserved from the yeast Saccharomyces cerevisiae to human. Core histone genes encode four families of proteins that package DNA into the nucleosome, which is the basic structural unit of eukaryotic chromosomes [1]. Most of the packaging of genomic DNA by core histones occurs primarily during the S phase of the cell cycle, when DNA is being actively replicated; stoichiometrically appropriate levels of histone proteins are required to bind DNA immediately following replication [6]. Much like the histone sequences, this histone gene expression pattern is highly conserved among eukaryotes ranging from human to the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe [8,9,10,11,12,13]
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