Abstract
Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner similar to instruction-embedded electronics, are rarely implemented. Here, we present design principles and demonstrations for gravity-driven, integrated, microfluidic pulsatile flow circuits. With a common gravity-head as the only driving force, these fluidic oscillator arrays realize a wide range of periods (0.4 s – 2 h) and flow rates (0.10 – 63 μL min−1) with completely independent timing between the multiple oscillator sub-circuits connected in parallel. As a model application, we perform systematic, parallel analysis of endothelial cell elongation response to different fluidic shearing patterns generated by the autonomous microfluidic pulsed flow generation system.
Highlights
Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented
Constantvoltage electronic circuit designs allow instructions to be embedded in the arrangement of circuit components in a way that multiple tasks can be performed autonomously and independently in parallel (Fig. 1a)
Similar to how low-voltage circuit design concepts were initially niche applications in the watch industry and later became indispensable in sophisticated electronics[21,22], we believe that scalable low-pressure hydraulic circuit design concepts will have implications beyond our initial cell applications to become critical modules for a broad range of sophisticated microfluidic operations
Summary
Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented. Microfluidic circuits, still require instruction from external controllers and do not Constant pressure-driven oscillator array How do the microhydraulic oscillator sub-circuits, described in this paper, trigger alternating valves to open and close with a constant input pressure (Pi)?
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