Multiple bonds crosslinked antibacterial, conductive and antioxidant hydrogel adhesives with high stretchability and rapid self-healing for MRSA infected motion skin wound healing

Abstract

Drug-resistant bacterial infection and low healing efficiency in motion skin wounds impose significant new requirements on design of wound dressings in terms of flexibility, self-healing, antibacterial activity, and multiple biological activities, and dressings mismatching the mechanical and biochemical properties of the wound will severely limit wound recovery. Herein, we developed a multiple bonds crosslinked antibacterial, conductive and antioxidant hydrogel adhesive with high stretchability and rapid self-healing for infected motion wound healing. The hydrogel is fabricated by one-pot photo-crosslinking the mixture of poly(glycerol sebacate)-co-poly(ethylene glycol)-g-catechol (PEGSD)/Zn2+/(3-acrylamidophenyl) boronic acid and 2-hydroxyethyl acrylate/ionic liquids (PEGSD-Zn2+/PHA-I) via multiple bonds crosslinking including coordination, hydrogen bond, phenylborate ester bond and permanent chemical bond. The in vitro antibacterial tests prove that Zn2+ incorporated polycationic hydrogel possesses excellent antibacterial property for MRSA and E. coli. Besides, the hydrogel has good cytocompatibility and antioxidation. The healing effect of hydrogel is demonstrated on the MRSA-infected mouse neck skin wound model, showing improved wound closing rate, collagen deposits and thickness of granulation tissue, due to the reduced inflammation and enhanced angiogenesis. In conclusion, the PEGSD-Zn2+/PHA-I hydrogel effectively promotes MRSA-infected motion wound healing and presents a new motion wound dressing design strategy of combining multiple biological activities and multiple bonds crosslinked network.