Abstract
BackgroundTo explore the epidemiologic and clinical features of, and interactions among, multipathogen infections in hospitalized children with acute respiratory tract infection (ARTI). A prospective study of children admitted with ARTI was conducted. Peripheral blood samples were analyzed by indirect immunofluorescence to detect respiratory agents including respiratory syncytial virus; adenovirus; influenza virus (Flu) types A and B; parainfluenza virus (PIV) types 1, 2, and 3; chlamydia pneumonia; and mycoplasma pneumonia. A medical history of each child was taken.ResultsRespiratory agents were detected in 164 (51.9%) of 316 children with ARTI. A single agent was identified in 50 (15.8%) children, and multiple agents in 114 (36.1%). Flu A was the most frequently detected agent, followed by Flu B. Coinfection occurred predominantly in August and was more frequent in children between 3 and 6 years of age. A significantly higher proportion of Flu A, Flu B, and PIV 1 was detected in samples with two or more pathogens per sample than in samples with a single pathogen.ConclusionOur study suggests that there is a high occurrence of multipathogen infections in children admitted with ARTI and that coinfection is associated with certain pathogens.
Highlights
Almost two million children die each year from acute respiratory tract infection (ARTI), and most of these children live in developing countries [1]
With recent advances in methods to detect respiratory agents, numerous studies have shown that some pediatric patients with acute lower respiratory tract infection become infected simultaneously with multiple respiratory viruses [8,9,10]
The aim of this study was to explore the epidemiologic and clinical features of, and interactions among, multipathogen infections in children hospitalized with ARTI in central China
Summary
Almost two million children die each year from acute respiratory tract infection (ARTI), and most of these children live in developing countries [1]. The etiologic agents of these common infections are respiratory syncytial virus (RSV); adenovirus (Adv); influenza virus (Flu) types A and B; parainfluenza virus (PIV) types 1, 2, and 3; chlamydia pneumonia (CP); and mycoplasma pneumonia (MP) [4]. The aim of this study was to explore the epidemiologic and clinical features of, and interactions among, multipathogen infections in children hospitalized with ARTI in central China. To explore the epidemiologic and clinical features of, and interactions among, multipathogen infections in hospitalized children with acute respiratory tract infection (ARTI). Peripheral blood samples were analyzed by indirect immunofluorescence to detect respiratory agents including respiratory syncytial virus; adenovirus; influenza virus (Flu) types A and B; parainfluenza virus (PIV) types 1, 2, and 3; chlamydia pneumonia; and mycoplasma pneumonia.
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