Multimodal neuroimaging verification of ganglioglioma associated with neuronal heterotopy in an adult patient without epileps

Abstract

Gangliogliomas are known to be rare and mainly slow-growing benign primary central nervous system tumors, most frequently occurring in children and young adults. They are the most common epilepsy-associated tumors, which frequent location is the temporal lobe. Surgery often seems to be the best approach in controlling seizures in such patients. This paper deals with a rare case of ganglioglioma in a young adult patient with a temporal lobe tumor associated with neuronal heterotopy of white matter, but without epilepsy. Long-term dynamic observation including in-depth clinical, electroencephalographic, radiologic, and postsurgical histologic examination confirmed the documented neoplastic process without any manifestation of seizures over ten years. Surgical intervention was based on the results of a multimodal radiological examination, which demonstrated the presence of neoplasm in the structure of the pathological substrate of unclear etiology.